Nkf Mdrd Calculator

NKF MDRD Equation:

\[ eGFR = 175 \times (Scr)^{-1.154} \times Age^{-0.203} \times (0.742 \text{ if female}) \times (1.212 \text{ if African American}) \]

Serum Creatinine (Scr):

mg/dL

Age:

years

Gender:

Race:

Estimated GFR (eGFR):

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1. What is the NKF MDRD Equation?

The NKF MDRD (Modification of Diet in Renal Disease) equation estimates glomerular filtration rate (GFR) from serum creatinine, age, sex, and race. It was developed by the National Kidney Foundation and provides a reliable assessment of kidney function, particularly for patients with chronic kidney disease.

2. How Does the Calculator Work?

The calculator uses the MDRD equation:

\[ eGFR = 175 \times (Scr)^{-1.154} \times Age^{-0.203} \times (0.742 \text{ if female}) \times (1.212 \text{ if African American}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( Age \) — Age in years
0.742 — Female multiplier
1.212 — African American race multiplier

Explanation: The equation uses a power function to model the inverse relationship between serum creatinine and GFR, with adjustments for age, gender, and race.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for diagnosing chronic kidney disease, monitoring disease progression, and determining appropriate treatment strategies and medication dosages.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, select gender and race. All values must be valid (creatinine > 0, age between 1-120).

5. Frequently Asked Questions (FAQ)

Q1: What is the difference between MDRD and CKD-EPI equations?
A: MDRD is more accurate for patients with established CKD (eGFR < 60), while CKD-EPI performs better across the full range of kidney function and is less likely to misclassify individuals with mildly reduced kidney function.

Q2: What are the limitations of the MDRD equation?
A: The equation may be less accurate in elderly patients, those with extreme body sizes, pregnant women, and populations with different muscle mass or dietary patterns.

Q3: When was the MDRD equation developed?
A: The MDRD equation was developed in 1999 and has been widely used for clinical assessment of kidney function.

Q4: Can this equation be used for drug dosing?
A: While MDRD-based eGFR is commonly used for drug dosing adjustments, some medications may require more precise GFR measurements in specific clinical situations.

Q5: How often should eGFR be monitored?
A: Monitoring frequency depends on the patient's clinical condition, but typically eGFR is checked at least annually in patients with risk factors for kidney disease.