1. What is SGOT/SGPT Ratio?

The SGOT/SGPT ratio (also known as AST/ALT ratio) is a calculation used in hepatology to help differentiate between various types of liver diseases. SGOT (Serum Glutamic-Oxaloacetic Transaminase) is now commonly referred to as AST (Aspartate Aminotransferase), and SGPT (Serum Glutamic-Pyruvic Transaminase) is now commonly referred to as ALT (Alanine Aminotransferase).

2. How Does the Calculator Work?

The calculator uses a simple ratio formula:

Where:

• \( SGOT \) — Aspartate Aminotransferase level (U/L)
• \( SGPT \) — Alanine Aminotransferase level (U/L)

Explanation: The ratio compares the levels of these two liver enzymes, which can provide insights into liver health and help differentiate between various liver conditions.

3. Clinical Significance

Details: The AST/ALT ratio is particularly useful in distinguishing between alcoholic liver disease (typically ratio >2) and viral hepatitis (typically ratio <1). It can also provide clues about cirrhosis, with ratios >1 often seen in advanced liver disease.

4. Using the Calculator

Tips: Enter both SGOT (AST) and SGPT (ALT) values in U/L. Both values must be greater than zero for the calculation to be valid.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal SGOT/SGPT ratio?
A: In healthy individuals, the ratio is typically around 1.0, with AST and ALT levels being approximately equal.

Q2: What does a high ratio (>2) suggest?
A: A ratio greater than 2 often suggests alcoholic liver disease, though it can also be seen in cirrhosis from other causes.

Q3: What does a low ratio (<1) indicate?
A: A ratio less than 1 is commonly seen in acute viral hepatitis and non-alcoholic fatty liver disease.

Q4: Are there limitations to this ratio?
A: Yes, the ratio should always be interpreted in the context of the complete clinical picture, including other liver function tests and patient history.

Q5: Should this ratio be used alone for diagnosis?
A: No, the AST/ALT ratio is a supportive tool and should be used in conjunction with other clinical findings, imaging studies, and laboratory tests for accurate diagnosis.